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Therapeutic vaccine candidates using viral vectors encoding LMP2 have successfully induced virus-distinct CD8⁺ T cell responses in early-period clinical trials. Also, adoptive T mobile therapies like posoleucel also goal LMP2 alongside other latency proteins which include EBNA1, reinforcing its importance as being a conserved and immunodominant antigen.
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Among these latency proteins, EBNA-3a performs a supportive but non-crucial job in B cell transformation: EBV mutants lacking EBNA-3a can nevertheless change B cells, but with significantly reduced efficiency.
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